Human Papillomavirus (HPV)
Research Drives Changes

HPV research is a major driver
in changing clinical practice

Published research papers show ultrasound probes are a potential source of HPV transmission, posing a new challenge for infection prevention.

Research reveals that virtually all cervical cancers (more than 99%) are caused by high-risk Human Papillomaviruses (HPV16 and HPV18 ). HPV is a highly resistant virus; more so than other non-enveloped viruses previously tested. 1,3

Published test results showed that commonly used clinical disinfectants, including those used as sterilants in medical and dental healthcare facilities, have no effect on HPV16 and HPV18.

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Pr Meyers - UVC radiation as an effective disinfectant method to inactivate - Research Paper
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Results suggest that healthcare facilities using endocavity ultrasound probes need to strongly consider disinfection methods that are effective against native HPV – adopting new technologies such as UV-C HLD. 2

Published test results prove that UVC radiation as an effective disinfectant method to inactivate human papillomaviruses (HPV16 and HPV18 ), whereas OPA showed minimal efficacy. 1-2

Hypernova Chronos is leading
the way in High Level Disinfection (HLD)

Chronos® automated UV-C High Level Disinfection (HLD) system is proven to kill native human papillomavirus (HPV) both in vitro and in clinical use.2-3

Chronos® automated UV-C High Level Disinfection (HLD) system is proven to kill native human papillomavirus (HPV) both in vitro and in clinical use.
  1. Meyers J, Ryndock E, Conway MJ, Meyers C, Robison R. Susceptibility of high-risk human papillomavirus type 16 to clinical disinfectants. J Antimicrob Chemother. 2014;69(6):1546-50.
  2. Meyers C, Milici J, Robison R (2017) UVC radiation as an effective disinfectant method to inactivate human papillomaviruses. PLoS ONE 12 (10): e0187377.
  3. Maxime Pichon, Karine LebailCarval, Geneviève Billaud, Bruno Lina, Pascal Gaucherand and Yahia Mekki (2019) Decontamination of Intravaginal Probes Infected by Human Papillomavirus (HPV) Using UV-C Decontamination System. J. Clin. Med, 8, 1776; doi:10.3390/jcm8111776.
  4. Johnson. S. et al.(2013) Evaluation of a Hydrogen Peroxide-Based System for High-Level
    Disinfection of Vaginal Ultrasound Probes, Journal of Ultrasound Medicine, 321799-804,
  5. Meyers C, et al. (2020). The ability of two chlorine dioxide chemistries to inactivate human papillomavirus-contaminated endocavitary ultrasound probes and nasendoscopes. doi:10.1002/jmv.25666. Epub 2020 Feb 4. PMID: 31919857; PMCID: PMC7497195.
  6. C. Kyriacou, et al (2021) Time effectiveness and convenience of transvaginal ultrasound probe disinfection using ultraviolet vs chlorine dioxide multistep wipe system: prospective survey study. https://doi.org/10.1002/uog.24834
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